PATHOLOGICAL MECHANISMS OF CONNEXIN26-RELATED HEARING LOSS: POTASSIUM RECYCLING, ATP-CALCIUM SIGNALING, OR ENERGY SUPPLY?

Pathological mechanisms of connexin26-related hearing loss: Potassium recycling, ATP-calcium signaling, or energy supply?

Hereditary deafness is one of the most common human birth defects.GJB2 gene mutation is the most genetic etiology.Gap junction protein 26 (connexin26, Cx26) encoded by the GJB2 gene, which is responsible for intercellular substance transfer and signal communication, plays a critical role in hearing acquisition and maintenance.The auditory character

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Methotrexate Treatment Suppresses Monocytes in Nonresponders to Pneumococcal Conjugate Vaccine in Rheumatoid Arthritis Patients

Patients with rheumatoid arthritis (RA) have an increased risk of infections; therefore, immunization against vaccine-preventable diseases is important.Methotrexate (MTX) impairs the antibody response to pneumococcal conjugate vaccine (PCV) in patients with arthritis, and the underlying mechanism is largely unknown.Here, we investigate the potentia

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A distributed approach to the regulation of clinical AI.

Regulation is necessary to ensure the safety, efficacy and equitable impact of clinical artificial intelligence (AI).The Dinner Forks number of applications of clinical AI is increasing, which, amplified by the need for adaptations to account for the heterogeneity of local health systems and inevitable data drift, creates a fundamental challenge fo

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